2,347 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division

    Fenghui Guan et al.
    Structural and functional approaches unambiguously revealed physiologically relevant lateral interactions between FtsZ protofilaments.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Architecture of the ring formed by the tubulin homologue FtsZ in bacterial cell division

    Piotr Szwedziak et al.
    The architecture of the bacterial cytokinetic ring in cells and in artificial liposome reconstitutions has been described using electron microscopy, leading to a mechanism of constriction.
    1. Genetics and Genomics

    Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

    Paul RHJ Timmers et al.
    Genomic associations with lifespan principally reflect heart disease/smoking/dementia but not other cancers, and distinguish lifespan differences of five years between top/bottom deciles of a score derived from DNA alone.
    1. Neuroscience

    Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators

    Simon Chamberland et al.
    The combination of a new genetically encoded voltage indicator and fast two-photon imaging methods enables detection of rapid neural electrical activity in organotypic slice cultures and in living flies.
    1. Neuroscience

    Across-species differences in pitch perception are consistent with differences in cochlear filtering

    Kerry MM Walker et al.
    Humans and other animals have different strategies for extracting the pitch of sounds, potentially driven by the species-specific frequency selectivity of the ear.
    1. Developmental Biology

    Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

    Haruko Nakano et al.
    During cardiogenesis, the major role of glucose is not the catabolic extraction of energy but the anabolic biosynthesis of nucleotides.
    1. Neuroscience

    Complexity of frequency receptive fields predicts tonotopic variability across species

    Quentin Gaucher et al.
    The A1 of ferrets and mice show similar tonotopic organizations, with neurons preferring a single frequency being more precisely organized into a tonotopic map than multipeaked neurons.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

    Elias T Friman et al.
    OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.
    1. Neuroscience

    Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech

    Melissa J Polonenko, Ross K Maddox
    The response from discrete stages of the early auditory pathway can be measured by subtle manipulations to long-form natural speech stimuli paired with deconvolution analysis of electroencephalography data.
    1. Microbiology and Infectious Disease

    A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria

    Félix Ramos-León et al.
    Identification of a novel regulator that directly influences the assembly and function of the cell division machinery in industrially and medically important bacteria.

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