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    1. Neuroscience

    Impaired spatial memory codes in a mouse model of Rett syndrome

    Sara E Kee et al.
    Hypersynchrony in a mouse model of Rett syndrome impairs ripple-dependent memory consolidation and leads to a decrease in experience-dependent refinement of place cell activities.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

    Pierre Khoueiry et al.
    Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
    1. Structural Biology and Molecular Biophysics

    Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7

    Fuzhou Ye et al.
    DNA mimicry Ocr protein, a well-studied T7 phage protein that inhibits host restriction enzymes, can also inhibit host transcription through competing with sigma factors in binding to RNA polymerase.
    1. Developmental Biology

    Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration

    Kieran M Short et al.
    Analysing developing mouse kidneys demonstrates nephron formation does not significantly impact branching morphogenesis of the ureteric bud, suggesting this process is distinct from branching in organs like the mammary gland.
    1. Cancer Biology

    eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

    Hang Ruan et al.
    Genetic and transcriptomic analyses revealed that eIF4E S209 phosphorylation enables Myc and mutant KRAS cooperation in colon cancer through stress- and glutamine-dependent growth and addiction.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

    Claire Y Ma et al.
    The strength of TCR signalling determines the rate at which cells initiate a tightly coordinated signalling programme, without altering its organization.
    1. Ecology

    Modelling the climatic suitability of Chagas disease vectors on a global scale

    Fanny E Eberhard et al.
    The global ensemble forecasting niche modelling of 11 vector competent triatomine species revealed climatic suitable regions outside their native distribution including the cosmopolitan vector Triatoma rubrofasciata.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

    David M Kern et al.
    The basis for small-molecule block, insights into gating, and an unexpected architectural role for the lipid membrane are revealed in structures of the volume regulated anion channel LRRC8A.
    1. Plant Biology

    Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

    Alexey Shapiguzov et al.
    Signalling and metabolic interactions of the plant energy organelles, chloroplasts and mitochondria, depend on the nuclear regulatory protein RCD1.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Computationally-driven identification of antibody epitopes

    Casey K Hua et al.
    The combination of computational modeling and protein design can reveal key determinants of antibody‚Äďantigen binding and optimize small sets of antigen variants for efficient experimental localization of epitopes.