The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.

Yeast promoters can harbor multiple natural DNA variants that influence gene expression, interact genetically, evolve under negative selection, alter transcription factor motifs, and remain challenging to predict.

The GARP complex is important for the endocytic recycling of amino phospholipid flippases and cell wall proteins, and thus membrane and lipid organization in yeast.

Modeling the evolution of PRDM9 in light of recent results implicating the importance of PRDM9 binding symmetry suggests the advantage of new PRMD9 alleles is in limiting the number of binding sites used effectively rather than increasing net binding.

shinyDepMap helps users explore the essentiality, selectivity, and function of the genes across hundreds of cancer cell lines and identify cancer drug targets.

Examination of the changes in the transcription start site selection in TCL1-driven chronic lymphocytic leukemia and their impact on mRNA translation revealed a marked elevation of intra-genic cryptic promoters, which are predicted to generate multiple N-terminally truncated or modified proteins.

A genetic screen in a unicellular photosynthetic organism uncovers the first essential signaling component in the chloroplast unfolded protein response that relays information from the chloroplast to the nuclear compartment.

Biochemical and genetic approaches uncover a chromatin remodeler for PRDM9 binding and the parallel local epigenetic modification of cytosines in mouse spermatocytes.

A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.