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    1. Cancer Biology
    2. Computational and Systems Biology

    Dissecting transcriptional amplification by MYC

    Zuqin Nie et al.
    Synthetic biology experiments show that MYC is a general transcription amplifier acting at two or more sites in the transcription-cycle and that MYC-turnover contributes to its activity.
    1. Neuroscience

    Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

    Naomi AK Hanemaaijer et al.
    High-speed calcium imaging from the axon initial segment shows that sodium channels are in part permeable to calcium ions.
    1. Neuroscience

    Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA

    Se Joon Choi et al.
    HCN and SK channel currents in striatal cholinergic neurons are decreased with dopamine loss, but only HCN is restored by chronic L-DOPA and SK abnormality persists in dyskinesia.
    1. Developmental Biology

    Intrinsic control of muscle attachment sites matching

    Alexandre Carayon et al.
    1. Neuroscience

    3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation

    Chih-Tung Lin et al.
    The new drug 3,6’-dithiopomalidomide mitigates key markers of neuronal death and neuroinflammation and improves acute behavioral outcome measures in traumatic brain injury, a common, debilitating disorder that lacks effective treatment.
    1. Chromosomes and Gene Expression

    Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants

    Lucas D Serdar et al.
    Nucleotide resolution mapping of ribosome-bound RNA decay fragments in yeast cells expressing ATPase-deficient UPF1 reveals 3' UTR bound ribosomes and a role for UPF1 in post-termination ribosome recycling.
    1. Neuroscience

    Neural Circuits: Turning away from danger

    Jun Liu, Monika Scholz
    The flexible escape behavior exhibited by C. elegans in response to threats relies on a combination of feedback and feedforward circuits.
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    1. Biochemistry and Chemical Biology

    Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

    Nicole L Jenkins et al.
    As worms age reduced glutathione together with increased ferrous iron increases frailty and leads to ferroptosis, which is amenable to therapeutic intervention.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs

    Robert T Todd, Anna Selmecki
    Novel segmental chromosome amplifications in Candida albicans provide rapid adaptation to the most widely used antifungal drugs.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

    Roger Pique-Regi et al.
    The human placenta negligibly co-expresses the transcripts encoding the canonical cell-entry mediators for SARS-CoV-2, which explains why mothers with COVID-19 rarely transmit the virus to the fetus.