The poorly characterized BTB-protein SPOPL is required to maintain the function of the late endosomal system and the endocytic adaptor EPS15 is therein targeted by the SPOPL/Cullin-3 ubiquitin ligase complex for degradation.
FGF signalling is responsible for priming the developmental enhancer ZRS across the distal limb mesenchyme during development, allowing ETS factors to modulate its activity through balancing histone acetylation.
Resting-state MEG-activity and MRS-GABA/Glx measurements reveal that there is a significant shift in excitability during the course of schizophrenia, involving hyperexcitability during the onset and a reduction at chronic stages.
Individual participant data meta-analysis reveals the estimated lifespan trajectory of cortical GABA, characterized by an early rapid increase, followed by a period of stability during early adulthood, and a gradual decrease.
Motivation for flight and feeding behaviour requires dopamine release which depends on cholinergic stimulation and intracellular Ca2+ release from ER stores in one or two pairs of central dopaminergic neurons.
The pervasive transcription environment alters the efficiency of firing of replication origins, which are 'protected' by roadblock termination due to origin recognition complex (ORC) and pre-RC complexes.