1,519 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

    Yosuke Yoneyama et al.
    IRS-1, a canonical signaling mediator of IGF-I receptor, serves as an endocytic regulator of IGF-I receptor to facilitate the sustained IGF signaling.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors

    Silvia Peluso et al.
    FGF signalling is responsible for priming the developmental enhancer ZRS across the distal limb mesenchyme during development, allowing ETS factors to modulate its activity through balancing histone acetylation.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Using evolution to generate sustainable malaria control with spatial repellents

    Penelope Anne Lynch, Mike Boots
    The evolution of insecticide-avoidance behaviour can be used to generate new spatial repellents to keep malaria vectors out of homes.
    1. Neuroscience

    A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity

    Masahiro Yamashita et al.
    Human neuroimaging and machine learning reveals a generalizable relationship between brain connectivity and working memory ability across healthy populations and distinct psychiatric diagnoses.
    1. Neuroscience

    Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation

    Sebastian C Holst et al.
    Multi-modal imaging, genetic and behavioral findings in humans and mice revealed that metabotropic glutamate receptors of subtype 5 contribute to the molecular machinery keeping track of sleep need and coping with physiological and behavioral consequences of sleep loss, pointing to novel targets for improved wakefulness and sleep.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Pervasive transcription fine-tunes replication origin activity

    Tito Candelli et al.
    The pervasive transcription environment alters the efficiency of firing of replication origins, which are 'protected' by roadblock termination due to origin recognition complex (ORC) and pre-RC complexes.
    1. Neuroscience

    Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working memory

    Matthew M Nour et al.
    Striatal dopamine 2/3 receptor (D2/3R) availability is related to working memory-induced functional connectivity changes in the default mode network, and this mediates the relationship between D2/3Rs and task performance.
    1. Neuroscience

    Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages

    Tineke Grent-'t-Jong et al.
    Resting-state MEG-activity and MRS-GABA/Glx measurements reveal that there is a significant shift in excitability during the course of schizophrenia, involving hyperexcitability during the onset and a reduction at chronic stages.

Refine your results by:

Type
Research categories