742 results found
    1. Neuroscience

    Controlling motor neurons of every muscle for fly proboscis reaching

    Claire E McKellar et al.
    A new collection of fly strains comprehensively targets the motor neurons of the proboscis, allowing separate control of every muscle to determine how this appendage achieves flexible, directed reaching.
    1. Plant Biology

    Lack of evidence for associative learning in pea plants

    Kasey Markel
    A fully blinded replication of the most convincing report of associative learning in plants failed to reproduce the phenomenon.
    1. Evolutionary Biology
    2. Neuroscience

    True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field

    Francisco M Nadal-Nicolás et al.
    Unique 'true' S-cone and S-cone bipolar cell distribution patterns in the mouse retina are previously unappreciated anatomical features that support enhanced short-wavelength signaling for color detection above horizon.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia

    Santosh Kumar Kuncha et al.
    Identification of a two-tier functional redundancy to combat proteostasis imbalance induced due to tRNA expansion and oxidative stress in multicellular animals.
    1. Cell Biology
    2. Developmental Biology

    Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation

    Pieter R Norden et al.
    Genetic and molecular analyses show that FOXC1 and FOXC2 play a role in controlling lymphatic valve maintenance as key mediators of mechanotransduction to control cytoskeletal organization and RhoA/ROCK signaling.
    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Damage-responsive, maturity-silenced enhancers regulate multiple genes that direct regeneration in Drosophila

    Robin E Harris et al.
    The reduced ability of Drosophila imaginal discs to regenerate as they mature can be explained by the silencing of damage-responsive enhancers that regulate expression of genes required for regeneration.
    1. Developmental Biology
    2. Evolutionary Biology

    Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer

    Iryna Kozmikova, Zbynek Kozmik
    Wnt/beta-catenin signaling is essential for the specification of dorsal cell fate in amphioxus, suggesting a common evolutionary origin for the formation of the dorsal organizer in chordates.

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