In contrast to amniotes, zebrafish (ray-finned fish, teleost) centra are formed from specialised notochord sheath cells, and the segmental patterning of these cells is independent of the segmentation clock.
Inducing presomitic mesoderm (PSM)-fated ES cells clarified that Ripply2 directly interacts with Tbx6 and degrades Tbx6 in proteasome-ubiquitin pathway by recruiting the 26S proteasome, which is a PSM-specific event to define the segment border during mouse somitogenesis.
A discovery of two previously unknown, molecularly distinct fields of cardiac progenitors in zebrafish provides evidence for cardiac laterality prior to the emergence of cardiac septation and allows novel insights into cardiac development and disease.
During aging, the pancreatic endocrine islets undergo chronic inflammation, which is associated with a reduced capacity for self-renewal of the insulin-producing beta-cells in zebrafish.
A specialized conduction pathway for the electrical impulse in the heart, previously thought to be associated with the endothermic mammals and birds only, is also present in the ectothermic crocodiles.
Emx2 mediates the directional selectivity of neuromasts by regulating hair bundle orientation in hair cells, and by selecting afferent neuronal targets.
