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The loss of Mecp2 results in cerebellar dysfunction that contributes to the motor deficits in Rett syndrome.

Purkinje cell dendritic calcium response is finely controlled by the burst activity of climbing fiber during sensory coding.

Targeted genetic silencing and reporter labeling reveal that Purkinje cell activity organizes cerebellar basket cells into zonal modules based on the sizes of their projections.

Computational and theoretical models show that rate adaptation of phase responses can regulate Purkinje cell outputs by forming transient oscillations in fast-spiking neurons.

Medial cerebellar nucleus comprises five major types of excitatory projection neurons differentially connected with specific subsets of inferior olive neurons, Purkinje cells, and somatomotor, oromotor, positional-autonomic, orienting and arousal circuits.

High-end technical approaches help to untangle the substructure and projection patterns of the cerebellum.

Anatomical projections from sensory, motor, and association cortex to the cerebellum are precisely mapped, including cortical-precerebellar connections and terminal organization, providing insight into how the cerebellum may utilize cortical information.

Electrophysiological and computational approaches show that superficial and deep cerebellar granule cells preferentially fire during low- and high-frequency inputs, respectively, enabling a Fourier-like transformation in the granule cell layer.

A bioinformatics pipeline has annotated over 2,500 complete genomes of circular DNA viruses belonging to dozens of established and emerging viral families.

New studies examine how the different sub-structures in the cerebellum are organized to receive information during complex behavioral tasks.