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    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Discovery of methylfarnesoate as the annelid brain hormone reveals an ancient role of sesquiterpenoids in reproduction

    Sven Schenk et al.
    A small brain-derived lipid prevents bristle worms from entering maturation and death, challenging current views of hormone evolution and pesticide specificity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti et al.
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    1. Developmental Biology

    Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

    Shen Yue et al.
    Smurf1 and Smurf2 have essential functions in the mammalian Shh signaling pathway, binding to and ubiquitylating Patched1, leading to its endocytosis and subsequent degradation in lysosomes.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Using paired serology and surveillance data to quantify dengue transmission and control during a large outbreak in Fiji

    Adam J Kucharski et al.
    A combination of surveillance data, paired sera and mathematical modelling reveals which factors may influence dengue transmission and control in island settings.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

    Nicole Toepfner et al.
    The morphology and deformability of all blood cells can be measured continuously and with high throughput directly in whole blood without prior enrichment or separation.
  1. Publishing scientific images using the IIIF

    The International Image Interoperability Framework (IIIF) makes the world’s image repositories interoperable and accessible.
  2. ReFigure logo

    ReFigure – connecting scientific insights across the web

    Introducing ReFigure, an open-source browser extension for linking, curating and sharing scientific insights across publishers.
  3. March roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in March 2017, including New Scientist, The New York Times and more.
  4. Annual report: 2016 in review

    A look back at eLife's achievements in 2016, notably in advocating for more open practises in sciences, building an open infrastructure for research communication and supporting early-career researchers.