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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization

    Zhong-Yu Liu et al.
    A conserved element in the flavivirus genomic 5′ terminus switches its conformation in response to long-range RNA interactions, and thereby regulates the dynamic recruitment of viral replicase for efficient viral RNA replication.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Comparative analysis of viral RNA signatures on different RIG-I-like receptors

    Raul Y Sanchez David et al.
    An experimental approach allowing characterization of viral RNA ligands recognized by RIG-I-like receptors during infection by any RNA viruses is established and validated.
    1. Microbiology and Infectious Disease

    Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

    Alex C Stabell et al.
    An analysis of innate immunity reveals why dengue viruses do not reach high titers in primate laboratory models, even though they emerged through zoonotic transmission from primate reservoirs.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Tracking interspecies transmission and long-term evolution of an ancient retrovirus using the genomes of modern mammals

    William E Diehl et al.
    Endogenous virus sequences in the genomes of modern mammals reveal the global spread of an ancient virus lineage, including frequent interspecies transmission, adaptation, and emergence spanning several million years of mammalian evolution
    1. Ecology
    2. Epidemiology and Global Health

    Using mobile phones as acoustic sensors for high-throughput mosquito surveillance

    Haripriya Mukundarajan et al.
    Mobile phones can accurately capture sound recordings from mosquito wingbeats with species-specific frequencies, together with metadata about the recording time, location and conditions, to enable rapid low-cost mosquito surveillance using a citizen-science approach.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus

    Parikshit Bagchi et al.
    Biochemical and cell-based analyses reveal how a non-enveloped virus exploits the chaperone activity of an ER transmembrane protein to penetrate the ER membrane required for successful virus infection.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the mechanism of the DEAH-box RNA helicase Prp43

    Marcel J Tauchert et al.
    The structural and functional analysis of the ATP-dependent RNA helicase Prp43 provides insights into the mechanisms of RNA binding and translocation, which could serve as paradigm for all DEAH-box proteins.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Evaluating probabilistic dengue risk forecasts from a prototype early warning system for Brazil

    Rachel Lowe et al.
    The evaluation of a dengue early warning system demonstrates its potential to assist dengue prevention and control up to three months ahead of future epidemics.
    1. Ecology
    2. Epidemiology and Global Health

    Temperature explains broad patterns of Ross River virus transmission

    Marta Strecker Shocket et al.
    Accounting for nonlinear responses to temperature is critical for accurately predicting how Ross River virus and other mosquito-borne diseases will respond to climate change and detecting the effects of temperature on disease transmission.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

    Sarah Gilbertson et al.
    Messenger RNA degradation alters protein trafficking to control transcription.