Big data analysis, protein structure prediction, and artificial intelligence are integrated to predict novel and highly transmissible SARS-CoV-2 variants.
Attentional modulation is affected by target-distractor similarity, indicating tuning sharpening as the underlying mechanism for response enhancement during object-based attention.
Aging reduces the potassium M current in sympathetic motor neurons, resulting in a hyperactive phenotype that can be reversed by pharmacological activation of these channels.
The amphipathic helix at the C-terminus of Complexin II prevents premature secretion, whereas its N-terminal domain regulates mechanisms which are governed by the forward rate of Ca2+ binding to Synaptotagmin I.
Clément Mazeaud, Stefan Pfister ... Laurent Chatel-Chaix
Through interactions with viral RNA and NS5, Zika virus changes the composition of the IGF2BP2-containing ribonucleoprotein complex for the benefit of the viral RNA amplification step of its life cycle.
Although activity in mouse V1 increases substantially during volitional running, such modulations in the foveal/central representation of primate V1 appear much smaller and suppressive.
