12 results found
    1. Cancer Biology
    2. Evolutionary Biology

    Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk

    Juan M Vazquez, Vincent J Lynch
    Duplication of tumor suppressor genes contributed to the evolution of large, long-lived elephants.
    1. Cell Biology
    2. Evolutionary Biology

    Evolutionary Biology: How elephants beat cancer

    Stephen J Gaughran, Evlyn Pless, Stephen C Stearns
    Version of Record
    Insight
    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak, Lindsey Fong ... Vincent J Lynch
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.
    1. Cancer Biology
    2. Evolutionary Biology

    Parallel evolution of reduced cancer risk and tumor suppressor duplications in Xenarthra

    Juan Manuel Vazquez, Maria T Pena ... Vincent J Lynch
    Sloths, armadillos, and anteaters evolved genetic and cellular traits that make them remarkably cancer resistant.
    1. Ecology

    Humans disrupt access to prey for large African carnivores

    Kirby L Mills, Nyeema C Harris
    The presence of humans induces behavioral modifications in many large carnivore and ungulate species, restructuring spatiotemporal relationships between African predators and their prey.
    1. Cell Biology
    2. Evolutionary Biology

    A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

    Omaya Dudin, Andrej Ondracka ... Iñaki Ruiz-Trillo
    Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Tracking interspecies transmission and long-term evolution of an ancient retrovirus using the genomes of modern mammals

    William E Diehl, Nirali Patel ... Welkin E Johnson
    Endogenous virus sequences in the genomes of modern mammals reveal the global spread of an ancient virus lineage, including frequent interspecies transmission, adaptation, and emergence spanning several million years of mammalian evolution
    1. Evolutionary Biology

    Rampant tooth loss across 200 million years of frog evolution

    Daniel J Paluh, Karina Riddell ... David C Blackburn
    Teeth are maintained in two amphibian groups (caecilians and salamanders) but were lost in frogs over 20 times independently, a higher incidence of edentulism than any other major vertebrate group.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Pan-mammalian analysis of molecular constraints underlying extended lifespan

    Amanda Kowalczyk, Raghavendran Partha ... Maria Chikina
    Cancer control, DNA repair, and immunity are key functionalities underlying the evolution of extended lifespan in mammals.
    1. Neuroscience

    Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats

    Kristina M Wright, Thomas C Jhou ... Michael A McDannald
    Ventrolateral periaqueductal gray neurons signal fear output through patterned inhibition of neural activity.

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