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    1. Computational and Systems Biology
    2. Plant Biology

    Computational modeling and quantitative physiology reveal central parameters for brassinosteroid-regulated early cell physiological processes linked to elongation growth of the Arabidopsis root

    Ruth Großeholz, Friederike Wanke ... Klaus Harter
    The recurring application of computational modelling combined with wet lab experiments identify and predict central regulatory parameters and factors for early cell physiological reactions linked to differential brassinosteroid-modified elongation growth in the root tip of Arabidopsis thaliana.
    1. Ecology
    2. Evolutionary Biology

    Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions

    Samuel Frederick Mock Hart, Chi-Chun Chen, Wenying Shou
    Mutations that directly benefit both self and cooperative partner can readily evolve to promote cooperation.
    1. Plant Biology

    Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain

    Aleksandra Białas, Thorsten Langner ... Sophien Kamoun
    The HMA domains of Pikp-1 and Pikm-1 NLR receptors have convergently evolved to bind AVR-PikD with high affinity through distinct evolutionary and biochemical paths.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genetic factors of bilaterian evolution

    Peter Heger, Wen Zheng ... Thomas Wiehe
    Advanced orthology clustering of bilaterian and non-bilaterian sequences identifies 157 bilaterian-specific genes which are linked to key morphological features of this animal group.
    1. Ecology
    2. Evolutionary Biology

    Host-parasite coevolution promotes innovation through deformations in fitness landscapes

    Animesh Gupta, Luis Zaman ... Justin R Meyer
    An interdisciplinary approach combining high throughput genotype-to-phenotype mapping, population genetic simulations, and experimental evolution provides an answer to the question of how populations evolve new functions by providing tests of the role antagonistic coevolution plays in pressuring populations to innovate.
    1. Epidemiology and Global Health
    2. Plant Biology

    Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management

    Elizabeth A Savory, Skylar L Fuller ... Jeff H Chang
    The horizontal acquisition of virulence plasmids is potentiated by production practices in plant nurseries and is sufficient to transition Rhodococcus from being beneficial to being pathogenic.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots

    Philip Bejon, Thomas N Williams ... Steffen Borrmann
    Malaria 'hotspots' can be identified that range in size from a few homesteads to a village, and it will be necessary to eliminate hotspots at varying scales as we progress towards eliminating malaria.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade

    Audrey A Burnim, Matthew A Spence ... Nozomi Ando
    A large-scale phylogenetic inference of the ribonucleotide reductase family reveals a new distinct clade with implications on how nature adapted to environmental changes.
    1. Computational and Systems Biology

    Inferring characteristics of bacterial swimming in biofilm matrix from time-lapse confocal laser scanning microscopy

    Guillaume Ravel, Michel Bergmann ... Simon Labarthe
    A new mathematical method has been developed, implemented and validated for the analysis of time-lapse confocal laser scanning microscopy images to characterize the swimming behavior of bacterial swimmers moving in the exogenous matrix of pathogenic biofilms.
    1. Immunology and Inflammation

    Diversity and functional specialization of oyster immune cells uncovered by integrative single cell level investigations

    Sébastien de La Forest Divonne, Juliette Pouzadoux ... Emmanuel Vignal
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing