11 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins

    Anna Caballe et al.
    ULK3 is a kinase in the abscission checkpoint that temporarily inactivates ESCRT-III proteins via phosphorylation, which is required to delay cytokinesis in response to defects in mitosis.
    1. Cancer Biology
    2. Cell Biology

    Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing

    Lauren K Williams et al.
    Cytoplasmic bodies sequester important abscission machinery to delay completion of cytokinesis in response to mitotic errors.
    1. Cell Biology

    A novel checkpoint pathway controls actomyosin ring constriction trigger in fission yeast

    Tomás Edreira et al.
    In fission yeast cell wall stress triggers a cytokinesis blockage specifically in the onset of actomyosin ring constriction.
    1. Cell Biology

    Ubiquitin turnover and endocytic trafficking in yeast are regulated by Ser57 phosphorylation of ubiquitin

    Sora Lee et al.
    Ser57 phosphorylation regulates ubiquitin homeostasis by inhibiting deubiquitylase-mediated recycling and promoting vacuolar degradation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

    Timothy J Wendorff, James M Berger
    The engagement of DNA crossings is shown to license ATP hydrolysis and DNA cleavage by topoisomerase VI, a finding with mechanistic ramifications for related GHKL ATPases and meiotic recombination machineries.
    1. Cell Biology
    2. Plant Biology

    Delivery of endocytosed proteins to the cell–division plane requires change of pathway from recycling to secretion

    Sandra Richter et al.
    The same membrane trafficking cargo can change pathways mediated by different members of ARF-GEF family of vesicle formation regulators.
    1. Cell Biology

    Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

    James Holder et al.
    Selective APC/C-mediated proteolysis of cyclin B drives progression through the metaphase-anaphase transition whilst wide-spread waves of dephosphorylation co-ordinate the subsequent events of mitotic exit.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of directional genetic interactions in a metazoan cell

    Bernd Fischer et al.
    A systematic analysis of gene–gene dependencies using high-throughput imaging of cells detects causal and temporal relationships between genes.
    1. Microbiology and Infectious Disease

    The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

    Declan L Turner et al.
    The HCMV virion envelope is derived from the host exosome membrane, and exosome machinery and export pathways facilitate virion egress.
    1. Cell Biology

    Mammalian cell growth dynamics in mitosis

    Teemu P Miettinen et al.
    High-resolution single-cell mass accumulation and protein synthesis rate measurements are used to quantify the extent, dynamics and consequences of animal cell growth in mitosis and cytokinesis.

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