526 results found
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Developmental Biology

    A universal reading network and its modulation by writing system and reading ability in French and Chinese children

    Xiaoxia Feng, Irene Altarelli ... Ghislaine Dehaene-Lambertz
    A cross-cultural study of reading acquisition and reading irmpairment reveals the invariance of the neural correlates of reading across cultures.
    1. Computational and Systems Biology
    2. Neuroscience

    A synergistic workspace for human consciousness revealed by Integrated Information Decomposition

    Andrea I Luppi, Pedro AM Mediano ... Emmanuel A Stamatakis
    Anaesthesia and disorders of consciousness both reduce the capacity of the human brain to integrate information, specifically targeting interactions within a shared circuit of regions in the brain’s default network.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

    Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
    Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
    1. Chromosomes and Gene Expression

    Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development

    Li Zhou, Mandy Yu Theng Lim ... Katsutomo Okamura
    Selective degradation of mature miRNAs shapes temporal miRNA expression patterns and is important for proper regulation of target genes to support normal development of Drosophila embryos.
    1. Neuroscience

    Automated long-term recording and analysis of neural activity in behaving animals

    Ashesh K Dhawale, Rajesh Poddar ... Bence P Ölveczky
    A new automated system for recording and analyzing neural activity in behaving animals over months-long time-scales offers new perspectives on how neural circuits underlie processes such as learning, development, and recovery from brain injury.
    1. Epidemiology and Global Health
    2. Medicine

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay, Emre Kiciman ... Andrey Rzhetsky
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Neuroscience

    Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice

    Janine Traut, Jose Prius Mengual ... Lukas B Krone
    The two most commonly used chemogenetic actuators, clozapine-N-oxide and compound 21, similarly modulate sleep in wild-type laboratory mice indicating that even designer drugs which do not convert to clozapine can elicit behavioural effects and require adequate controls.
    1. Neuroscience

    Intrinsic mechanical sensitivity of mammalian auditory neurons as a contributor to sound-driven neural activity

    Maria C Perez-Flores, Eric Verschooten ... Ebenezer N Yamoah
    In vitro and in vivo physiological analyses reveal that mammalian auditory neuron intrinsic mechanical sensitivity contributes to sound-evoked activity and explains other previously unexplained auditory neuron features.
    1. Neuroscience

    TMS-evoked responses are driven by recurrent large-scale network dynamics

    Davide Momi, Zheng Wang, John D Griffiths
    Whole-brain computational modelling, incorporating novel ML-based parameter estimation techniques, reveals how transcranial magnetic stimulation-evoked brain responses are driven at earlier timepoints by local echoes of the external stimulus, and at later timepoints by large-scale network reverberation across the connectome.

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