2,283 results found
    1. Cell Biology

    Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals

    Fabian Schueren et al.
    Whole-genome in silico screening for stop codon contexts that produce elevated translational readthrough and peroxisome targeting reveals that in mammals, the amount of lactate dehydrogenase in the peroxisome is controlled by translational readthrough.
    1. Computational and Systems Biology

    Control and regulation of acetate overflow in Escherichia coli

    Pierre Millard et al.
    Elucidating the control and regulation of acetate overflow in E. coli reveals that acetate is not only an end-product but also a co-substrate and a global regulator of glucose metabolism.
    1. Cancer Biology

    Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

    Tushar D Bhagat et al.
    Lactate in pancreatic cancer micro-environment can lead to TET enzyme activation and loss of DNA methylation seen in cancer associated fibroblasts.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

    Jeffrey I Boucher et al.
    The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.
    1. Developmental Biology

    The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle

    Husniye Kantarci et al.
    Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.
    1. Biochemistry and Chemical Biology

    A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells

    Sina Ibne Noor et al.
    Carbonic anhydrase II features a surface proton antenna that exclusively mediates proton exchange with monocarboxylate transporters to facilitate proton-coupled lactate transport in cancer cells.
    1. Medicine
    2. Neuroscience

    AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa

    Yunlu Xue et al.
    AAV-Txnip prolongs vision in mouse models of blindness, enhancing lactate catabolism, mitochondrial health, and ATP production in a condition that likely has a limited glucose supply.
    1. Evolutionary Biology
    2. Neuroscience

    A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina

    Christian Damsgaard et al.
    A novel mode of oxygen delivery facilitated the adaptive evolution of vision in teleost fishes.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolic interactions between dynamic bacterial subpopulations

    Adam Z Rosenthal et al.
    Metabolic division of labor in B. subtilis controls the extracellular environment.
    1. Ecology
    2. Microbiology and Infectious Disease

    Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior

    Caleb N Fischer et al.
    Interactions between fungal and bacterial microbiome members alter Drosophila melanogaster's chemical environment, affecting host behavior and survival.

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