644 results found
    1. Cell Biology
    2. Neuroscience

    DIO-SPOTlight Transgenic Mouse to Functionally Monitor Protein Synthesis Regulated by the Integrated Stress Response

    Matthew L Oliver, Zachary F Caffall ... Nicole Calakos
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins

    Sharon Inberg, Yael Iosilevskii ... Benjamin Podbilewicz
    Mechanosensory isolation of C. elegans nematodes independently induces homeostatic structural changes in the dendritic tree and differential response to mechanical stimulation, both these structural and behavioral outcomes are mediated by degenerins and do not affect presynaptic calcium dynamics.
    1. Neuroscience

    Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons

    Shun Hiramatsu, Kokoro Saito ... Hiromu Tanimoto
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Barcode activity in a recurrent network model of the hippocampus enables efficient memory binding

    Ching Fang, Jack Lindsey ... Selmaan Chettih
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Fractal cycles of sleep, a new aperiodic activity-based definition of sleep cycles

    Yevgenia Rosenblum, Mahdad Jafarzadeh Esfahani ... Martin Dresler
    Polysomnographical analysis in humans shows that temporal fluctuations of aperiodic neural activity reflect the cycling nature of sleep.
    1. Genetics and Genomics

    High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models

    Thomas J O'Brien, Ida L Barlow ... André EX Brown
    High-throughput animal tracking and quantitative behaviour analysis detects diverse phenotypes in genetic disease models at a scale that makes drug screens possible.
    1. Neuroscience

    Quantification of the effect of hemodynamic occlusion in two-photon imaging

    Baba Yogesh, Matthias Heindorf ... Georg B Keller
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

    Ryosuke Isotani, Masaki Igarashi ... Toshimasa Yamauchi
    Nicotine affects intestinal stem cells rather than Paneth cells, resulting in the increased stemness and tumorigenicity of intestinal stem cells.
    1. Immunology and Inflammation
    2. Medicine

    JAK inhibition decreases the autoimmune burden in Down syndrome

    Angela L Rachubinski, Elizabeth Wallace ... Joaquín M Espinosa
    Treatment with a JAK inhibitor normalizes multiple biomarkers of autoinflammation and provides therapeutic benefit for diverse immune skin conditions in individuals with Down syndrome.

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