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Muscarinic acetylcholine receptor type A in adult Drosophila inhibits Kenyon cells, and is required for aversive olfactory learning and learning-associated synaptic depression between Kenyon cells and their output neurons.

Pharmacological and genetic studies in the mouse reveal how dopamine D2 receptors on cholinergic interneurons regulate cue-evoked changes in the levels of striatal acetylcholine and dopamine during behavior.

The neurotransmitter acetylcholine influences how male finches perform courtship songs by acting on a region of the premotor cortex called HVC.

The protein disulphide isomerase CRELD1 controls the biosynthesis of nicotinic acetylcholine receptors in nematode and mouse muscle.

Reconstructed ancestral muscle-type acetylcholine receptor β-subunits readily form homopentameric ion channels that open spontaneously, and display functional hallmarks of the modern-day heteropentameric receptor despite being devoid of canonical agonist-binding sites.

Structural biology studies reveal the importance of protein dynamics on understanding molecular mechanisms underlying allosteric modulation of G protein-coupled receptors (GPCR) that offer insights into future GPCR research and drug discovery.

Neurons of the cholinergic system, which release the excitatory neurotransmitter acetycholine throughout the cortex, also release the inhibitory transmitter GABA, with potential implications for cognitive function.

Ligand-specific-induced conformations of M₃ muscarinic receptors reveal similar requirements for G protein-coupled receptor kinase 2 and G_q protein binding, whereas arrestin3 binding is mediated by distinct receptor conformations.

Acetylcholine plays a multifold role in modulating neuronal mismatch in auditory cortex, affecting the precision of prediction error signaling and gating prediction errors to hierarchically higher processing levels.

Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.