280 results found
    1. Cell Biology

    Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids

    Patrick C Hoffmann et al.
    Combining cerebral organoid technology with cryo-correlative microscopy reveals the organization of cytoskeleton, membrane compartments, and protein synthesis machinery contributing to the rapid expansion of developing human axons.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

    Daniel Porto et al.
    Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

    Vinay V Eapen et al.
    A combination of spatial proteomic and autophagic flux approaches was used to reveal the landscape of turnover of damaged lysosomes, demonstrating a key role for the autophagy receptor TAX1BP1 and its associated kinase TBK1 in both HeLa cells and iNeurons.
    1. Neuroscience

    Switch-like and persistent memory formation in individual Drosophila larvae

    Amanda Lesar et al.
    A new computer controlled behavioral assay and integrated training chamber for individual Drosophila larvae shows that larvae learn all at once and create long-term memories that last overnight.
    1. Evolutionary Biology

    Quantifying the relationship between genetic diversity and population size suggests natural selection cannot explain Lewontin’s Paradox

    Vince Buffalo
    Quantifying the relationship between census sizes and genetic diversity estimates provides insights into whether natural selection can explain the narrow range of diversity between species.
  1. Research Culture: Creating SPACE to evolve academic assessment

    Ruth Schmidt et al.
    The San Francisco Declaration on Research Assessment (DORA) has developed a new tool called SPACE to support universities and institutions working to improve the assessment of research.
    1. Neuroscience

    Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

    Weisheng Wang et al.
    Activity in the hypothalamic dorsal premammillary nucleus predicts future escape from threat, represents escape velocity, and controls escape velocity via a projection to the brainstem.
  2. Annual Report: 2020 in review

    We reflect on eLife’s efforts to drive change in scientific and medical publishing during an eventful year.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

    Axel A Guzmán-Solís et al.
    The characterization of ancient B19V and HBV genotype A4 viruses circulating during Colonial epidemics provides new insights into the pathogens that were introduced to the Americas after the European colonization.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery

    Asli Azizoglu et al.
    A new gene expression tool enables precise control of protein dosage over a large range and paves the way for new genetic discoveries.

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