Aaron L Randolph, Younes Mokrab ... Ian Scott Ramsey
Electrophysiological and computational techniques provide a structural basis for understanding the conformational changes that are required to activate Hv1 proton channels.
Human cells adapt to chronic mild stresses, such as slightly elevated temperature, by getting larger in a process that couples increased translation to increased cell size in an Hsp90-dependent manner.
Katarina Valoskova, Julia Biebl ... Daria E Siekhaus
T antigen glycosylation, which marks metastatic cancer cells, is modulated on a small set of proteins by a conserved multipass transmembrane protein to allow tissue invasion by Drosophila macrophages.
Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.