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Proton channels are present in reef-building corals and constitute important molecular players that should help understand calcification and the response of these organisms to ocean acidification.

cAMP is identified to play a novel role in regulating DNA demethylation and gene transcription by augmenting the intracellular reactive Fe(II) pool.

An unbiased genome-wide human forward genetic screen identifies the vacuolar ATPase complex and assembly factors as regulators of HIF stability through their actions on intracellular iron metabolism.

The pathogenic success of Mycobacterium tuberculosis relies in part on its ability to blunt a component of the TLR2-dependent immune response.

The reduction of bicarbonate secretion into the airways reproduces cystic fibrosis-like features, independently of chloride secretion.

The cytoplasm behaves as an adaptable fluid that can reversibly transition into a protective solid-like state upon stress.

In mitotically aging yeast cells, the cytosol acidifies, the distances between the organellar membranes decrease dramatically, but crowding on the scale of the average size protein is relatively stable.

Storage of solar energy in the thylakoid electrical field by photosynthesis in vivo can substantially destabilize charge-separated states in photosystem II, leading to singlet oxygen production and photodamage, contributing to loss of productivity, especially under fluctuating light experienced in the field.

Emerin, a protein that plays key roles in nuclear organization, can be dynamically degraded in response to environmental stimuli such as ER stress.

Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.