50 results found
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production

    Blake R Wilde et al.
    The MondoA transcription factor localizes to the outer mitochondrial membrane where it coordinates an adaptive transcriptional response to elevated cellular energy represented by high cytoplasmic glucose and high mitochondrial ATP.
    1. Neuroscience

    Transient acidosis while retrieving a fear-related memory enhances its lability

    Jianyang Du et al.
    Activating ASIC channels in the amygdala makes a single reminder more effective at rendering consolidated fear memories labile and susceptible to modification.
    1. Cell Biology
    2. Neuroscience

    Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

    Yi-Zhi Wang et al.
    An interaction between the ion channel ASIC1a and the protein RIP1 is responsible for neuronal death caused by tissue acidosis.
    1. Cancer Biology
    2. Medicine

    A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis

    Ming Chao et al.
    Local infusion of bicarbonate into hepatocellular carcinoma markedly enhances local tumor control by transarterial chemoembolization.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis

    Ponni Rajagopal et al.
    Small decreases in pH associated with cellular stress conditions unleash a cryptic mode of client binding in a ubiquitously expressed human small heat shock protein that is more effective at delaying client aggregation.
    1. Neuroscience

    Polyglycerol-opioid conjugate produces analgesia devoid of side effects

    Sara González-Rodríguez et al.
    A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.
    1. Genetics and Genomics
    2. Medicine

    PTPRG is an ischemia risk locus essential for HCO3-dependent regulation of endothelial function and tissue perfusion

    Kristoffer B Hansen et al.
    HCO3-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.
    1. Cell Biology
    2. Developmental Biology

    Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

    Max Werth et al.
    A combination of genetic and molecular assays revealed that transcription factor Tfcp2l1 provides the basis for cell patterning and physiologic coordination in kidney collecting ducts.
    1. Ecology
    2. Evolutionary Biology

    Reduced metabolism supports hypoxic flight in the high-flying bar-headed goose (Anser indicus)

    Jessica U Meir et al.
    Measurements of bar-headed geese flying in a wind tunnel in hypoxia reveal that these birds sustain aerobic flight at high altitude via a reduction in metabolism.

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