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Cell Biology
Structural Biology and Molecular Biophysics
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
Florian Ullrich, Sandy Blin ... Thomas J Jentsch
TMEM206 proteins are identified as constituting the pore of the widely expressed acid-activated chloride channel PAORAC/ASOR, which is important in acid toxicity.
Cell Biology
Neuroscience
Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction
Yi-Zhi Wang, Jing-Jing Wang ... Tian-Le Xu
An interaction between the ion channel ASIC1a and the protein RIP1 is responsible for neuronal death caused by tissue acidosis.
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