4,574 results found
    1. Computational and Systems Biology

    Removing unwanted variation with CytofRUV to integrate multiple CyTOF datasets

    Marie Trussart et al.
    CytofRUV is a computational algorithm that effectively enables batch effect reduction in multiple CyTOF batches with an adaptable normalisation method and an R-Shiny application with diagnostics plots.
    1. Microbiology and Infectious Disease

    The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport

    Matthew J Powers et al.
    An outer membrane vesicle pulse-chase assay demonstrates that the Acinetobacter baumannii Mla system is a retrograde lipid transporter.
    1. Neuroscience

    Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

    Javier Díaz-Alonso et al.
    Despite being the key element of the classic model for excitatory synaptic plasticity, the cytoplasmic AMPA receptor C-tail is not required for hippocampal LTP.
    1. Neuroscience

    Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1

    Vincent Huson et al.
    Modulation of the energy barrier for membrane fusion is a common mechanism by which sensors in the synapse produce supralinear calcium dependence of vesicle release and short-term synaptic potentiation.
    1. Computational and Systems Biology

    Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

    Anusorn Mudla et al.
    Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.
    1. Cell Biology

    WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity

    Emmanuelle Steib et al.
    Centriole integrity is ensured by the connection between the inner scaffold and microtubule triplets through POC16/WDR90 proteins.
    1. Cell Biology

    The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

    Kanji Okumoto et al.
    H2O2-induced phosphorylation at Ser232 of Pex14 spatiotemporally regulates peroxisomal import of catalase, functioning in counteracting action against oxidative stress by the increase of cytosolic catalase.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes

    Rashmi Voleti et al.
    Ca2+-free synaptotagmin-1 binds to neuronal SNARE complexes anchored on nanodiscs, and Ca2+ releases this interaction to induce tight, specific binding to PIP2-containing membranes.
    1. Cell Biology
    2. Neuroscience

    Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neurons

    Feline W Lindhout et al.
    A dynamic qualitative and quantitative map of human iPSC-derived neuronal stem cells transitioning into polarized neurons with the identification and characterization of a previously unrecognized axon developmental stage.
    1. Cancer Biology
    2. Cell Biology

    MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression

    Timothy J Aikin et al.
    The temporal patterns of MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncogene expression.

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