2,661 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse

    Catherine A Hartzell et al.
    By restricting actin polymerization to the perimeter of the immune synapse and promoting depolymerization, calcium influx drives centripetal actin flow, which confines CRAC channels and the endoplasmic reticulum to the synapse center.
    1. Cell Biology

    G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion

    Vladimir Purvanov et al.
    siRNA knockdown experiments reveal in detail the signaling pathway that controls cytoskeletal function during cell-in-cell invasion.
    1. Developmental Biology
    2. Neuroscience

    Robo2 regulates synaptic oxytocin content by affecting actin dynamics

    Savani Anbalagan et al.
    Real-time monitoring of oxytocin-loaded vesicles and synaptic actin dynamics in zebrafish reveal that Slit3-Robo2-Cdc42 signalling maintains steady-state levels of mature oxytocin neuropeptide readily primed to be secreted upon physiological demand.
    1. Developmental Biology

    Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination

    Ioannis Kasioulis et al.
    Microtubules are nucleated by the centrosome of the primary cilium in the apical end-foot of neuroepithelial cells and inter-dependent microtubule and actin dynamics are required here to orchestrate delamination of newborn neurons.
    1. Cell Biology

    Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

    Wei-ke Ji et al.
    A key cellular process is controlled by altering a balance, rather than through an off/on mechanism.
    1. Plant Biology

    Dynamic F-actin movement is essential for fertilization in Arabidopsis thaliana

    Tomokazu Kawashima et al.
    The movement of F-actin filaments, which is regulated by actin-myosin interactions together with a female gamete-specific Rho-GTPase, enables migration of the Arabidopsis sperm cell nucleus towards the female nucleus; which might account for the loss of centrosomes in flowering plants.
    1. Physics of Living Systems
    2. Cell Biology

    Side-binding proteins modulate actin filament dynamics

    Alvaro H Crevenna et al.
    The kinetics of actin polymerization are strongly influenced by the binding of proteins to the lateral filament surface.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation

    Joseph E Chambers et al.
    Monomeric actin forms a crucial component of the eIF2α holophosphatase linking the integrated stress response to actin polymeric status.
    1. Cell Biology
    2. Neuroscience

    Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts

    Moritz Armbruster et al.
    The recycling of transmitter vesicles at synapses shows calcium-dependent regulation that depends on the phosphorylation status of an enzyme called dynamin.
    1. Structural Biology and Molecular Biophysics

    Dynamic action of the Sec machinery during initiation, protein translocation and termination

    Tomas Fessl et al.
    The complex process of protein translocation across membranes has been dissected into multiple key steps and the distributions of translocation rates indicate stochastic nature of the reaction.

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