3,423 results found
    1. Structural Biology and Molecular Biophysics

    Structural basis of αE-catenin–F-actin catch bond behavior

    Xiao-Ping Xu et al.
    A molecular mechanism for force-dependent binding of the cell adhesion proteins αE-catenin and vinculin to actin is derived from the structure of the αE-catenin actin-binding domain bound to F-actin.
    1. Cell Biology

    Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast

    Jenna R Christensen et al.
    The contractile ring actin binding proteins tropomyosin Cdc8 and a-actinin Ain1 synergize to effectively compete with the endocytic actin patch protein fimbrin Fim1 for associating with F-actin networks.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed atomic force microscopy

    Kien Xuan Ngo et al.
    A cluster of cofilin along an otherwise bare actin filament induces distinctively asymmetric cooperative conformational changes to the filament on either side of the cluster.
    1. Cell Biology

    A plasma membrane template for macropinocytic cups

    Douwe M Veltman et al.
    Rings of actin polymerisation that form around PIP3/Ras patches in the cell membrane drive the formation of macropinocytic cups.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Visualizing the functional architecture of the endocytic machinery

    Andrea Picco et al.
    A combination of light and electron microscopy data provide new insights into the dynamic architecture and the function of the endocytic protein machinery in relation to membrane shape changes in vivo.
    1. Neuroscience

    Cellular resolution circuit mapping with temporal-focused excitation of soma-targeted channelrhodopsin

    Christopher A Baker et al.
    Combining spatial restriction of channelrhodopsin to the neuronal cell body with two photon excitation and calcium imaging will enable production of high resolution maps of neural circuitry.
    1. Physics of Living Systems

    Shared behavioral mechanisms underlie C. elegans aggregation and swarming

    Siyu Serena Ding et al.
    Two seemingly distinct behaviors in social C. elegans worms, namely aggregating into groups and swarming over food, are driven by the same underlying mechanisms.
    1. Neuroscience

    Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse

    Sooyun Kim et al.
    A novel mechanism of local plasticity in the distal dendrites of hippocampal granule cells.
    1. Cell Biology

    Direct comparison of clathrin-mediated endocytosis in budding and fission yeast reveals conserved and evolvable features

    Yidi Sun et al.
    Quantitative comparison of clathrin-mediated endocytosis in budding and fission yeast identified conserved mechanisms and species-specific adaptations with broad implications that extend from yeast to humans.

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