2,915 results found
    1. Developmental Biology and Stem Cells

    CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs

    Melanie I Worley et al.
    The CtBP protein stabilizes cell fates in regenerating tissue.
    1. Neuroscience

    Orphan receptor GPR158 controls stress-induced depression

    Laurie P Sutton et al.
    The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
    1. Cell Biology
    2. Genomics and Evolutionary Biology

    LINE-1 protein localization and functional dynamics during the cell cycle

    Paolo Mita et al.
    A combination of functional, biochemical and imaging studies show that LINE-1/L1 proteins and mRNA enter the nucleus through mitotic nuclear membrane breakdown, interact with components of the DNA replication fork and mediate retrotransposition during S phase.
    1. Genes and Chromosomes
    2. Immunology and Inflammation

    Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages

    Maria A Sacta et al.
    A comprehensive analysis of the glucocorticoid-sensitive pro-inflammatory genes in macrophages reveals fundamental differences between the temporal events and components of transcriptional machinery that the glucocorticoid receptor targets to repress their transcription.
  1. Meeting report: Visions and versions and the future of peer review

    Mark Patterson shares some perspectives after the recent ASAPbio meeting on Transparency, Recognition, and Innovation in Peer Review in the Life Sciences.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

    Kelda Chia et al.
    Pre-neoplastic cells in the brain release SDF1, which mediates an immediate infiltration of macrophages that differentiate into microglia-like cells and promote proliferation of pre-neoplastic cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translational control of ERK signaling through miRNA/4EHP-directed silencing

    Seyed Mehdi Jafarnejad et al.
    ERK/MAPK activity is regulated by the cap-binding protein 4EHP, via translational control of the DUSP6 phosphatase.
    1. Human Biology and Medicine
    2. Neuroscience

    Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease

    Roxanne Lofredi et al.
    Bradykinesia in Parkinson's disease may be associated to a dopamine-dependent recruitment failure of subthalamic activity in short bursts of gamma synchrony.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function

    Suihan Feng et al.
    Caged, photoactivatible sphingosine localized to mitochondria permits demonstration of the importance of subcellular localization on lipid metabolism and signaling.

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