117 results found
    1. Cell Biology
    2. Neuroscience

    Pharmacological brake-release of mRNA translation enhances cognitive memory

    Carmela Sidrauski, Diego Acosta-Alvear ... Peter Walter
    A compound that prevents stressors such as UV light and viral infection from downregulating protein synthesis inside cells improves memory performance in mice.
    1. Chromosomes and Gene Expression

    A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

    Nicole A Rapicavoli, Kun Qu ... Howard Y Chang
    A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.
    1. Cell Biology

    p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

    Senthil K Radhakrishnan, Willem den Besten, Raymond J Deshaies
    The enzyme p97/VCP regulates the activity of the transcription factor Nrf1 to promote increased transcription of genes that encode proteasome subunits following inhibition of the proteasome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Bacterial actin MreB forms antiparallel double filaments

    Fusinita van den Ent, Thierry Izoré ... Jan Löwe
    The prokaryotic actin homologue MreB forms antiparallel double filaments in vitro and in vivo, an architecture that is unprecedented among the actin family of proteins.
    1. Developmental Biology
    2. Neuroscience

    GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation

    Meghan Morgan-Smith, Yaohong Wu ... William D Snider
    The kinase GSK-3 regulates cortical neuronal migration and dendritic orientation by phosphorylating key cytoskeletal proteins.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    General principles for the formation and proliferation of a wall-free (L-form) state in bacteria

    Romain Mercier, Yoshikazu Kawai, Jeff Errington
    A wide range of bacterial species can switch into a cell wall-free state that does not require the FtsZ-based division machinery to proliferate.
    1. Neuroscience

    Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia

    Shanping Chen, Diancai Cai ... David L Glanzman
    Storage of long-term memory in Aplysia does not require stable synapses.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

    Ruming Chen, Cláudia Rato ... David Ron
    The biochemical basis for coupling cytoskeletal dynamics to regulated protein synthesis has been revealed.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

    Patrick Laurette, Thomas Strub ... Irwin Davidson
    The PBAF chromatin-remodelling complex is essential for the proliferation of melanocytes and melanoma cells and is recruited to critical regulatory elements by physical and functional interactions with MITF, a transcription factor and master regulator of melanoma.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Oxyntomodulin regulates resetting of the liver circadian clock by food

    Dominic Landgraf, Anthony H Tsang ... Henrik Oster
    The gut-released peptide oxyntomodulin mediates the alignment of liver clock gene and metabolic transcript rhythms with the timing of food intake by postprandial induction of hepatic Per gene expression.

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