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    1. Cell Biology
    2. Genetics and Genomics

    Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling

    Priyanka Das, Alejandro Aballay, Jogender Singh
    Calcineurin inhibition has opposing effects on Caenorhabditis elegans lifespan and survival on pathogens via its role in the defecation motor program.
    1. Neuroscience

    Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

    Zachary W Hoisington, Himanshu Gangal ... Dorit Ron
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall

    Carlos A Ramirez Carbo, Olalekan G Faromiki, Beiyan Nan
    A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall and thus transmits proton motive force from the inner membrane to cell surface.
    1. Cancer Biology

    Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

    Anne Fajac, Iva Simeonova ... Franck Toledo
    The male-specific tumor-suppressive effects of minor p53 isoforms were correlated with higher Ackr4 expression levels, which have implications for sex-specific cancer prognosis in humans.
    1. Cell Biology

    Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics

    Raymond Laboy, Marjana Ndoci ... Adam Antebi
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Plasticity of the proteasome-targeting signal Fat10 enhances substrate degradation

    Hitendra Negi, Aravind Ravichandran ... Ranabir Das
    Biophysical experiments, pulse-chase assays, and molecular dynamics simulations reveal how the proteasome targeting signal Fat10 can modulate the structure of substrate proteins to potentially regulate their degradation by the proteasome.
    1. Structural Biology and Molecular Biophysics

    The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

    Johannes N Greve, Anja Marquardt ... Dietmar J Manstein
    Mutation E334Q in cytoskeletal γ-actin leads to impaired interaction of actin filaments with actin-binding proteins belonging to the myosin and ADF/cofilin families.
    1. Cell Biology

    Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia

    Haoyang Wu, Peiyuan Lv ... Jiaji Lin
    An RNAi screen in mouse hippocampal neuronal cell line targeting epigenetic regulators revealed a novel neuroprotection of Prmt5 and uncovered its nucleus translocation feature and epigenetic mechanism in cerebral ischemia.
    1. Computational and Systems Biology

    Structural assembly of the bacterial essential interactome

    Jordi Gómez Borrego, Marc Torrent Burgas
    A new study reveals structural details of the bacterial essential interactome, opening new avenues for antibiotic discovery.