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    1. Microbiology and Infectious Disease

    A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall

    Carlos A Ramirez Carbo, Olalekan G Faromiki, Beiyan Nan
    A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall and thus transmits proton motive force from the inner membrane to cell surface.
    1. Neuroscience

    CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats

    Xiao-Wen Yu, Daniel M Curlik II ... John F Disterhoft
    Behavioral, biochemical, and biophysical analyses show that age-related memory deficits can be rescued by directly overexpressing wild-type CREB.
    1. Microbiology and Infectious Disease

    Membrane binding properties of the cytoskeletal protein bactofilin

    Ying Liu, Rajani Karmakar ... Martin Thanbichler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Protein gradients on the nucleoid position the carbon-fixing organelles of cyanobacteria

    Joshua S MacCready, Pusparanee Hakim ... Daniel C Ducat
    Carboxysomes, the carbon-fixation machinery of cyanobacteria, are equidistantly-positioned by dynamic gradients of the protein McdA on the nucleoid that emerge through interaction with a previously unidentified carboxysome factor, McdB.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Two different cell-cycle processes determine the timing of cell division in Escherichia coli

    Alexandra Colin, Gabriele Micali ... Sven van Teeffelen
    Chromosome replication and a different inter-division process both contribute to division control during unperturbed growth, but if division is delayed by increasing cell width the inter-division process becomes solely rate-limiting.
    1. Cancer Biology
    2. Cell Biology

    GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

    Jenna L Jewell, Vivian Fu ... Kun-Liang Guan
    Protein kinase A (PKA) phosphorylates Raptor and inhibits mammalian target of rapamycin complex 1 (mTORC1) activity.
    1. Microbiology and Infectious Disease

    Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

    Catherine Baranowski, Michael A Welsh ... E Hesper Rego
    Polar elongating mycobacteria (Mycobacterium smegmatis) require specific cell wall chemistries, those catalyzed by targets of critical antibiotics, to maintain rod shape at aging sites of the bacillus.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    General principles for the formation and proliferation of a wall-free (L-form) state in bacteria

    Romain Mercier, Yoshikazu Kawai, Jeff Errington
    A wide range of bacterial species can switch into a cell wall-free state that does not require the FtsZ-based division machinery to proliferate.
    1. Neuroscience

    ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

    Shu-Xia Cao, Ying Zhang ... Xiao-Ming Li
    Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

    Ruming Chen, Cláudia Rato ... David Ron
    The biochemical basis for coupling cytoskeletal dynamics to regulated protein synthesis has been revealed.