37 results found
    1. Ecology
    2. Microbiology and Infectious Disease

    Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across eastern North America

    Rita de Cassia Pessotti, Bridget L Hansen ... Matthew F Traxler
    The widespread occurrence of metabolically active streptomycetes in Odontotaenius disjunctus beetle frass may insulate their galleries against pathogenic fungal invasion through the production of diverse antimicrobial specialized metabolites.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Evolution of substrate specificity in a retained enzyme driven by gene loss

    Ana Lilia Juárez-Vázquez, Janaka N Edirisinghe ... Francisco Barona-Gómez
    An integrated biochemical and evolutionary analysis shows how enzyme specificity evolves after gene loss during genome decay, implicating relaxation of purifying selection as a driving force for functional divergence.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

    Cara C Boutte, Christina E Baer ... Eric J Rubin
    Cell wall biosynthesis in mycobacteria is regulated by an unusual post-translational regulatory system that contributes to antibiotic tolerance during stress.
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway

    Brittany K Miller, Ryan Hughes ... Miriam Braunstein
    SatS of Mycobacterium tuberculosis is a new protein export chaperone with a role in exporting proteins by the specialized SecA2 pathway and a role in intracellular growth in macrophages.
    1. Microbiology and Infectious Disease

    A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria

    Félix Ramos-León, Matthew J Bush ... Susan Schlimpert
    Identification of a novel regulator that directly influences the assembly and function of the cell division machinery in industrially and medically important bacteria.
    1. Microbiology and Infectious Disease

    Streptomyces exploration is triggered by fungal interactions and volatile signals

    Stephanie E Jones, Louis Ho ... Marie A Elliot
    Exploratory growth is a newly discovered mode of Streptomyces growth that it is stimulated by fungi, is pH responsive, and can be communicated to other – physically separated – streptomycetes through airborne compounds.
    1. Microbiology and Infectious Disease

    Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis

    Mehak Zahoor Khan, Debbie M Hunt ... Vinay Kumar Nandicoori
    CysM and CysK2 play complementary and overlapping roles in Mtb's adaptation to environmental stress that are crucial for survival.
    1. Ecology
    2. Microbiology and Infectious Disease

    A microbial clock provides an accurate estimate of the postmortem interval in a mouse model system

    Jessica L Metcalf, Laura Wegener Parfrey ... Rob Knight
    High-throughput sequencing has been used to analyze the microbiome of mouse corpses over a period of 48 days, and to provide an accurate estimate of the time since death.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Microbiome: Does disease start in the mouth, the gut or both?

    Andrei Prodan, Evgeni Levin, Max Nieuwdorp
    Oral bacteria colonize the gut more frequently than previously thought.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry

    Shuhua Thong, Bilge Ercan ... Shu-Sin Chng
    Auxiliary proteins play functional roles in modulating the assembly and activity of a non-canonical ABC transporter that is important for the maintenance of outer membrane lipid asymmetry.

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