2,585 results found
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

    James E Hughes Hallett et al.
    The key Target of Rapamycin Complex (TORC1) component Kog1 moves into bodies during glucose starvation to limit reactivation of the complex.
    1. Cell Biology

    Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

    Yidi Sun et al.
    Intersectin counterparts in yeast recruit WASP and WIP to endocytic sites to establish a robust multivalent SH3 domain-PRM interaction network which gives actin assembly onset a switch-like behavior in vivo.
    1. Immunology and Inflammation

    The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

    Zhengpeng Wan et al.
    The B cell receptors of naïve B cells need higher levels of mechanical force to be fully activated than those of memory B cells.
    1. Neuroscience

    Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex

    Sachiko Murase et al.
    Dark exposure lowers the MMP9 activation threshold, and subsequent light stimulation to an amblyopic eye is sufficient to induce proteolysis at thalamo-cortical synapses in deprived mouse visual cortex.
    1. Immunology and Inflammation

    High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

    Antoine Marçais et al.
    Chronic engagement of Natural killer cell inhibitory receptors by MHC-I molecules maintains a high activity of the mTOR pathway allowing subsequent amplification of signaling through activating receptors upon acute stimulation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell Cycle: Micromanaging checkpoint proteins

    Andrea Ciliberto, Silke Hauf
    The kinase Mps1, long known to be the 'boss' in mitotic checkpoint signaling, phosphorylates multiple proteins in the checkpoint signaling cascade.
    Insight
    Available as:
    • HTML
    • PDF
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Point of View: The challenges faced by living stock collections in the USA

    Kevin McCluskey et al.
    Living stock collections provide invaluable resources to research communities, yet they face significant challenges.
  1. Research: The readability of scientific texts is decreasing over time

    Pontus Plavén-Sigray et al.
    Scientific abstracts have become less readable over the past 130 years, in part because recent texts include more general scientific jargon than older texts.

Refine your results by:

Type
Research categories