Chromatin-binding proteins regulate the effective solvent quality experienced by chromatin and impact global chromatin organization in the nucleus.

Hox genes are activated sequentially and, at the same time, undergo a transition from an inactive to an active chromatin compartment, most likely to prevent posterior genes being activated too early.

Chromosomal structural ensembles are fluid yet are cell-type-specific, despite apparent disorder, appropriate collective variables uncover evidence of structural transitions associated with gene activity and cell differentiation.

Characterization of Drosophila female germ cell differentiation shows that nurse cells initiate Polycomb silencing by regulating Pcl and Scm levels to alter the biochemical properties of the PRC2 H3K27 methylase.

Genomic landmarks, known generically as ‘CpG islands’, program chromatin structure via their richness in the dinucleotide CG and their skewed composition of DNA bases.

Histone deacetylase 1 (Hdac1) plays a crucial role in maintaining differential histone acetylation states of enhancers in various germ layers and regulates the transcriptional program both temporally and spatially.

Computer simulations considering actions of the intranuclear enzyme, Topoisomerase-II, in a mechanistic scheme elucidated a capability of enzymes to contribute to controlling chromatin spatial organizations and discovered new characteristic features in eu- and heterochromatin organization caused by the enzymatic activity.

A computational model of fission yeast mitosis can interrogate mechanisms required for successful mitosis, the origin of spindle length fluctuations, and spindle force balance during assembly.

Within distinct chromatin landscapes, the BRG1 chromatin remodeling enzyme patterns hormone-dependent chromatin interactions, pioneer factor recruitment, and transcriptional activity.

MYCN and TFIIIC exert a censoring function during early transcription, limiting the accumulation of inactive RNAPII at the promoter and facilitating promoter-proximal degradation of nascent RNA.