1,518 results found
    1. Neuroscience

    A spiral attractor network drives rhythmic locomotion

    Angela M Bruno et al.
    The neural population of the Aplysia's pedal ganglion are a low-dimensional spiral attractor, and the parameters of the attractor directly define the properties of the Aplysia's escape locomotion behaviour.
    1. Developmental Biology
    2. Physics of Living Systems

    Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development

    Lokesh G Pimpale et al.
    Developmentally controlled chiral counter-rotating actomyosin flows drive cell-lineage spindle skews and cell rearrangements during cytokinesis in early nematode development.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

    Joseph M Cabral et al.
    Epigenetic restriction of herpes simplex virus occurs in a biphasic manner, in which ATRX maintains viral heterochromatin after an initial phase of chromatin deposition.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Geminivirus-encoded TrAP suppressor inhibits the histone methyltransferase SUVH4/KYP to counter host defense

    Claudia Castillo-González et al.
    A viral protein hijacks the key effector of transcriptional gene silencing, Su(var)3-9, to evade host plant surveillance.
    1. Developmental Biology
    2. Neuroscience

    A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

    Meenakshi Prajapati-DiNubila et al.
    Opposing gradients of activin A and follistatin within the spiral shaped mammalian cochlea instruct the graded pattern of mechano-sensory hair cell formation.
    1. Microbiology and Infectious Disease

    Apoptotic neurodegeneration in whitefly promotes the spread of TYLCV

    Shifan Wang et al.
    A plant virus, Tomato yellow leaf curl virus, manipulates the host preference of the vector insect whitefly to promote its transmission by inducing caspase-dependent apoptotic neurodegeneration in vector's brain.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

    Jeroen Witteveldt et al.
    MiRNA-mediated suppression of MAVS expression in embryonic stem cells is necessary to inactivate the type I interferon response.
    1. Cell Biology
    2. Immunology and Inflammation

    MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

    Siqi Liu et al.
    A cell-free system combined with cell-based assays elucidate the biochemical mechanism of signal transduction mediated by the mitochondrial protein MAVS and delineates the role of ubiquitin E3 ligases in antiviral innate immune responses.
    1. Cell Biology

    Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

    Huiliang Zhang et al.
    The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
    1. Developmental Biology
    2. Physics of Living Systems

    From local resynchronization to global pattern recovery in the zebrafish segmentation clock

    Koichiro Uriu et al.
    Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.

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