6,869 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Active machine learning-driven experimentation to determine compound effects on protein patterns

    Armaghan W Naik et al.
    In an investigation into the effects of drugs on proteins, an active machine learning algorithm chose which sets of experiments to perform and was able to learn an accurate model of the effects after doing only a fraction of the experiments.
    1. Computational and Systems Biology
    2. Neuroscience

    Dopamine role in learning and action inference

    Rafal Bogacz
    A mathematical model describes the function of dopaminergic neurons in both learning and action planning.
    1. Neuroscience

    The control of tonic pain by active relief learning

    Suyi Zhang et al.
    The brain has a central cortico-striatal learning circuit that suppresses ongoing pain after injury when actively learning about things that could remove the cause of the pain.
    1. Neuroscience

    Learning and recognition of tactile temporal sequences by mice and humans

    Michael R Bale et al.
    Mice and humans learned to distinguish an arbitrary tactile sequence from other stimuli that differed only in their temporal patterning over hundreds of milliseconds, showing that sequence learning generalises across sensory modalities.
    1. Neuroscience

    Computational mechanisms of curiosity and goal-directed exploration

    Philipp Schwartenbeck et al.
    Distinct computational levels of uncertainty compel agents to gain information about hidden states in the world (‘active inference’) or optimise their ‘world model’ as such (‘active learning’).
    1. Neuroscience

    New learning while consolidating memory during sleep is actively blocked by a protein synthesis dependent process

    Roi Levy et al.
    The brain inhibits the formation of new memories just after waking to safeguard the ongoing stabilization of existing memories during sleep.
    1. Neuroscience

    Learning induces the translin/trax RNase complex to express activin receptors for persistent memory

    Alan Jung Park et al.
    Combination of in vitro and in vivo approaches reveal how learning suppresses the microRNA system to trigger de novo synthesis of plasticity proteins, a missing link in the current model of microRNA-mediated translation in persistent synaptic plasticity and memory.
    1. Cell Biology
    2. Neuroscience

    Hearing: It takes two

    Teresa Nicolson
    Insight
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    1. Neuroscience

    A corticostriatal deficit promotes temporal distortion of automatic action in ageing

    Miriam Matamales et al.
    Acquisition of behavioral sequences in normally aged mice involves short and unusually fast patterns of action, some of which are reproduced by striatal circuitry manipulations in young mice and can be transitorily restored through action-related feedback.
    1. Cell Biology
    2. Neuroscience

    The synaptic ribbon is critical for sound encoding at high rates and with temporal precision

    Philippe Jean et al.
    The synaptic ribbon regulates calcium channel clustering and proper vesicle dynamics at cochlear inner hair cells to ensure precise sound encoding.

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