CRISPR/Cas9 gene editing in mice reveals that diverse functions of actin isoforms are defined by their nucleotide, rather than their amino acid sequence, suggesting a novel mechanism of nucleotide-dependent protein regulation in eukaryotic genomes.

Perception of vibrotactile frequency depends on the neural discharge pattern rather than the afferent type, thus requiring a reevaluation of the notion of Pacinian/non-Pacinian channels in tactile sensory system.

Signalling and metabolic interactions of the plant energy organelles, chloroplasts and mitochondria, depend on the nuclear regulatory protein RCD1.

A new machine-learning toolbox unveils coevolutionary protein motifs related to structure, function, and phylogeny from sequence information only.

In the brain of medaka fish, neuropeptide B acts directly downstream of estrogen in a female-specific but reversible manner to mediate female receptivity to male courtship.

ATP imaging of spiking optic nerve axons in real time reveals correlation between ATP levels and electrical activity as well as contribution of lactate metabolism to axonal ATP homeostasis.

Slow conformational changes after drug binding rationalize selectivity, affinity and long on-target residence time for kinase inhibitors.

Tactile edge orientation processing during object manipulation is many times better than previously thought based on perceptual studies.

Neurons from individuals with higher IQ scores have larger dendrites, are able to maintain faster action potentials, and thus process information more efficiently.

Membrane receptor proteins move through primary cilia largely by passive diffusion rather than by active intraflagellar transport.