637 results found
    1. Stem Cells and Regenerative Medicine
    2. Developmental Biology

    Hair follicle epidermal stem cells define a niche for tactile sensation

    Chun-Chun Cheng et al.
    Heterogeneous epidermal stem cells define a niche for tactile sensation via providing a unique ECM and tissue architecture for nerves, revealing their new functions in coordinated sensory organ formation.
    1. Neuroscience

    Peripheral optogenetic stimulation induces whisker movement and sensory perception in head-fixed mice

    Sunmee Park et al.
    Light can be used to trigger the contraction of facial muscles and movement of the whiskers in transgenic mice, aiding the study of active sensation.
    1. Neuroscience

    Tapered whiskers are required for active tactile sensation

    Samuel Andrew Hires et al.
    The tapered, conical shape of rodent whiskers is essential for sensor mobility in constrained spaces and feature extraction from textured surfaces.
    1. Neuroscience

    A unified internal model theory to resolve the paradox of active versus passive self-motion sensation

    Jean Laurens, Dora E Angelaki
    Central vestibular regions in the brainstem and cerebellum perform dynamic Bayesian inference to combine motor commands and sensory signals into an optimal estimate of self-motion.
    1. Microbiology and infectious disease

    Asymmetric division triggers cell-specific gene expression through coupled capture and stabilization of a phosphatase

    Niels Bradshaw, Richard Losick
    Asymmetric cell division is linked to cell-specific transcription by handoff of a key developmental regulator from the cytokinetic machinery to the adjacent cell pole where it oligomerizes to become stabilized and activated.
    1. Neuroscience

    Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans

    Calogero Maria Oddo et al.
    Delivering specific patterns of electrical activity to the median nerve of the arm triggers reliable sensations of texture, suggesting that it may ultimately be possible to restore complex tactile information to users of prosthetic limbs.
    1. Neuroscience

    Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

    Francie Moehring et al.
    Keratinocytes are critical for normal innocuous and noxious touch through their mechanically evoked ATP release and subsequent signaling to P2X4 channels on sensory neurons.
    1. Medicine
    2. Neuroscience

    Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis

    Jianxi Zhu et al.
    Osteoblastic PGE2 induces pain and OA progression by NaV1.8 modification and serves as a potential target multiple skeletal pain and degenerations.
    1. Neuroscience

    Interactions between respiratory oscillators in adult rats

    Robert TR Huckstepp et al.
    Active expiration in anesthetized rats is driven by the lateral parafacial region, but requires an additional form of excitation from another source.
    1. Neuroscience

    Diminished responses to bodily threat and blunted interoception in suicide attempters

    Danielle C DeVille et al.
    People who have attempted suicide exhibit blunted sensory processing during breathing and pain perturbations, as well as lower heartbeat perception accuracy and reduced mid/posterior insula activity during interoceptive attention.

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