Microscopic and biochemical analysis show that the stress-activated MAP kinase pathway targets the formin For3 to modulate actomyosin ring integrity in response to environmental cues.
Cytokinetic actomyosin ring disassembly occurs through a novel mechanism in which the increased ring curvature, generated through contraction, itself promotes the disassembly process.
Asymmetric tension increase along the cell equator promotes self-organization of actomyosin into a partially aligned network during cytokinetic cleavage furrow ingression of vertebrate cells.
Novel mechanisms for cellular centering and symmetry breaking involving persistent contractile actomyosin flows and their hydrodynamic interactions with the fluid cytosol are presented and studied using a minimal, reconstituted system.
Combining quantitative biological experiment and physical description of actomyosin cortex reveals a contractile instability in the cortex of C. elegans embryo, and its biochemical control in order to robustly drive morphogenetic events.
Developmentally controlled chiral counter-rotating actomyosin flows drive cell-lineage spindle skews and cell rearrangements during cytokinesis in early nematode development.