104 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring et al.
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.
    1. Developmental Biology

    LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility

    Hyang Mi Moon et al.
    Novel insights into LIS1-dependent regulation of cell membrane contractility and cleavage axis specification identify a key molecular network regulating mitoses of neural progenitors and somatic cells during development.
    1. Developmental Biology
    2. Neuroscience

    Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth

    Alexandre B Roland et al.
    Cannabinoids inhibit neuronal expansion and growth through the rapid contraction of actomyosin.
    1. Cancer Biology
    2. Cell Biology

    Cell Proliferation: The ROCKs on which tumour cells thrive

    Simon Wilkinson, Margaret C Frame
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    1. Cancer Biology
    2. Cell Biology

    Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

    Sandra Kümper et al.
    The Rho kinases ROCK1 and 2 act redundantly in regulating cell proliferation and their depletion causes cellular senescence.
    1. Cell Biology
    2. Developmental Biology

    Protein phosphatase 1 activity controls a balance between collective and single cell modes of migration

    Yujun Chen et al.
    Protein phosphatase 1 activity promotes cohesive collective cell migration by restricting actomyosin contractility to the periphery of the collective and maintaining proper cadherin–catenin complex protein levels at cell–cell junctions.
    1. Physics of Living Systems
    2. Developmental Biology

    Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

    Tae-Jin Kim et al.
    Deep penetration and transmission of mechanical force to regulate ER functions depends on not only the passive cytoskeletal support, but also the active actomyosin contractility, which is dispensable for mechanotransduction at the plasma membrane.
    1. Cell Biology
    2. Computational and Systems Biology

    An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes

    Hamdah Shafqat-Abbasi et al.
    “Discontinuous” and “Continuous” migration modes are divergent mesenchymal migration strategies that arise spontaneously in parallel in an equilibrium modulated by cell-matrix attachment and actomyosin contractility.
    1. Cancer Biology
    2. Cell Biology

    Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

    Benjamin L Ricca et al.
    In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.

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