Phylogenetic and computational methods reveal that at least two seasonal coronaviruses are evolving adaptively in the region of the viral spike protein exposed to the human humoral immune system.
Jenny L Witten, Veronika Lukyanova, Wolf M Harmening
High-resolution foveal imaging and micro-psychophysics reveal that the human oculomotor system finely adjusts drift motion of the eye in an acuity task to enhance retinal sampling, achieving sub-cell resolution.
Natasha M O'Brown, Brian R Summers ... David M Kingsley
An identical DNA base pair change has occurred in divergent sticklebacks to alter the expression of a major developmental gene controlling armor plates, thus providing a molecular link between particular enhancer changes, cell signaling, and repeated skeletal evolution in natural populations.
Jingsong Zhang, Jessica Cunningham ... Robert Gatenby
Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
A series of selective events, each improving fitness relative to an immediate predecessor, can result in organisms that are less fit compared to a distant ancestor.
The timescale dependence of dN/dS in bacteria is better explained by adaptive than purifying dynamics, suggesting comparative genomics can underestimate past adaptation.
Robert Horvath, Nikolaos Minadakis ... Anne C Roulin
Disentangling the different selective forces shaping the evolutionary dynamics of transposable elements (TEs) in the wild grass Brachypodium distachyon.
A new model describes how adaptive molecular evolution shapes phylogenetic trees and can be used to estimate the fitness effects of mutations from phylogenies.
Ageing is broadly accepted as a by-product of evolution, as thus, models allowing to conceive ageing as an adaptive force of evolution could show significant importance at a time of biogerontology mostly aiming at curing ageing.