The T-cell receptors of gamma delta (γδ) T cells can recognize and trigger responses to small molecules and are thereby versatile drivers of immunity.

Immune cell motility and vascular response are imaged in vivo and label free in the CNS for the first time, using high-resolution phase-contrast adaptive optics retinal imaging.

IL-6 signaling in T cells controls how sensitive they are to suppression by T regulatory cells, and the way mature to become memory T cells.

Longitudinal transcriptomic analysis of unvaccinated patients reveals that early NK cell cytotoxicity activation distinguishes mild from severe COVID-19, supporting the relevance of concerted innate–adaptive immune responses against the virus.

A phase transition of TIR-1/SARM1 induced by either pathogen or non-pathogen stress potentiates its intrinsic NADase activity, which activates the p38 PMK-1 signaling cascade to induce protective immune defenses in Caenorhabditis elegans intestinal epithelial cells.

The T cell repertoire can display immunodominance to an epitope as a result of optimal positive selection in the thymus by one self-peptide/MHC ligand.

AXL enables the priming of the antiviral adaptive immune response by limiting the production of type I interferons in dendritic cells.

Actively regulated immune memory differentiation, with a preference for cross-reactive receptors with moderate affinity against pathogens as opposed to high-affinity receptors, confers a long-term benefit to the host.

In a study of a herpes simplex virus (HSV) vaccine, the combination of sex and prior exposure to the virus resulted in HSV naive women mounting a prominent type I interferon response associated with reduced neutralizing titers to HSV.