903 results found
    1. Neuroscience

    Human foveal cone photoreceptor topography and its dependence on eye length

    Yiyi Wang et al.
    Despite evidence of retinal stretching with eye growth, cone photoreceptor sampling density in the foveal center of humans actually increases with eye length.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Imaging single-cell blood flow in the smallest to largest vessels in the living retina

    Aby Joseph et al.
    By using a specialized camera that corrects for eye blur, millions of single-blood-cells are imaged, and their speed measured, as they travel through the largest-to-smallest vessels of the retina.
    1. Cell Biology
    2. Neuroscience

    2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics

    Sheena A Josselyn
    Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Point of View: Looking back and looking forward at Janelia

    Gerald M Rubin, Erin K O'Shea
    The Janelia Research Campus opened its doors 12 years ago: we describe the philosophy underpinning Janelia, the lessons learned, and plans for the future.
    1. Ecology
    2. Evolutionary Biology

    The Natural History of Model Organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution

    David M Parichy
    The zebrafish is a premier model organism for biomedical research, with a rich array of tools and genomic resources, and combining these with a fuller appreciation of wild zebrafish ecology could greatly extend its utility in biological research.
  1. Point of View: Unbridle biomedical research from the laboratory cage

    Garet P Lahvis
    Recent advances in technology now make it possible to carry out biomedical research on animals living in the wild, or captive animals living in naturalistic conditions.
  2. Research: Theory, models and biology

    Wenying Shou et al.
    Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.
    Editorial
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    1. Cancer Biology

    Science Forum: Challenges in validating candidate therapeutic targets in cancer

    Jeffrey Settleman et al.
    More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.

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