189 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Regulation by the quorum sensor from Vibrio indicates a receptor function for the membrane anchors of adenylate cyclases

    Stephanie Beltz et al.
    A canonical class III adenylate cyclase with a membrane anchor of six transmembrane spans is regulated by a receptor of similar design, the quorum-sensing receptor from Vibrio harveyi.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

    Radim Osicka et al.
    A toxin produced by the bacterium Bordetella pertussis preferentially binds to non-activated integrin complement receptor 3 outside of its ligand-binding I-domain and efficiently blocks downstream signaling of the integrin through elevation of cytosolic cAMP.
    1. Neuroscience

    PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

    Rachel A Ross et al.
    Genetic and pharmacological approaches demonstrate that pituitary adenylate cyclase-activating polypeptide neurons from the ventral premamillary nucleus of the hypothalamus regulate reproductive function by modulating the activity of a subset of Kiss1 neurons in the female mouse.
    1. Neuroscience

    Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

    Shogo Haraguchi et al.
    Diurnal variation loss of pineal allopregnanolone synthesis by light-at-night induces pituitary adenylate cyclase-activating polypeptide (PACAP) reduction and transcriptional PACAP repression in the cerebellum, with subsequent Purkinje cell death.
    1. Biochemistry and Chemical Biology

    The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

    Januka S Athukoralage et al.
    The dynamic interplay between type III CRISPR enzymes governs cyclic nucleotide levels and infection outcomes in virus-host conflict.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

    Nikolai Petkau et al.
    Acetylation of the circadian transcription factor BMAL1 by the acetyltransferase TIP60 is crucial for recruitment of the pause release factors to clock gene promoters and productive elongation of these genes.
    1. Cell Biology
    2. Neuroscience

    Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

    David Moreno Delgado et al.
    Innovative approaches were used to identify the specific pharmacological properties of heterodimeric metabotropic glutamate receptors composed of mGlu2 and mGlu4 subunits, and reveal their existence in a neuronal cell line and in perforant path terminals.
    1. Biochemistry and Chemical Biology

    Cdc48-like protein of actinobacteria (Cpa) is a novel proteasome interactor in mycobacteria and related organisms

    Michal Ziemski et al.
    Cdc48-like protein of actinobacteria (Cpa) is a AAA+ proteasomal interactor involved in adaptation of mycobacteria to carbon limitation and potentially influencing ribosomal composition of the cell.
    1. Biochemistry and Chemical Biology

    Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

    Januka S Athukoralage et al.
    A widespread ribonuclease is a CRISPR-associated ring nuclease with a highly unusual cooperative mechanism involving tetramerisation of the enzyme.
    1. Cell Biology

    A novel biosensor to study cAMP dynamics in cilia and flagella

    Shatanik Mukherjee et al.
    A new FRET-based cAMP biosensor with nanomolar sensitivity makes it possible to measure cAMP dynamics in miniscule subcellular compartments like cilia and flagella.

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