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    1. Cell Biology
    2. Immunology and Inflammation

    Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility

    Akira Takeda, Daichi Kobayashi ... Eiji Umemoto
    A lipid mediator lysophosphatidic acid (LPA) derived from fibroblastic reticular cells regulates T-cell movement through the densely packed reticular network in lymph nodes in a manner dependent on the LPA receptor LPA2-ROCK-myosin II.
    1. Cell Biology

    The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells

    Anjali Teckchandani, Jonathan A Cooper
    A ubiquitin E3 ligase localizes to focal adhesions at the front of migrating human cells where it regulates cytoskeletal dynamics by targeting a focal adhesion protein.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14

    Kathrin Tomasek, Alexander Leithner ... Michael Sixt
    By binding with their type 1 pili to the cell surface receptor CD14, pathogenic E. coli suppress the capacity of dendritic cells to activate T cells.
    1. Developmental Biology

    Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis

    Daniel Sieiro, Anne C Rios ... Christophe Marcelle
    In chick skeletal muscle, an incoming signal leads to two interdependent outcomes: a cell fate change and an epithelial-mesenchymal transition.
    1. Cell Biology
    2. Developmental Biology

    Proliferation-independent regulation of organ size by Fgf/Notch signaling

    Agnė Kozlovskaja-Gumbrienė, Ren Yi ... Tatjana Piotrowski
    Cell adhesion regulates organ size in the zebrafish lateral line system.
    1. Developmental Biology
    2. Medicine

    CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

    Hironobu Okuno, Francois Renault Mihara ... Hideyuki Okano
    Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
    1. Cell Biology
    2. Physics of Living Systems

    Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity

    Jacopo Di Russo, Jennifer L Young ... Joachim P Spatz
    The use of nanopatterned hydrogels and specific integrin α5β1 peptidomimetic revealed that keratinocytes require an optimum inter-ligand spacing to best propagate intercellular forces and efficiently coordinate cell sheet migration.
    1. Neuroscience

    Endoglycan plays a role in axon guidance by modulating cell adhesion

    Thomas Baeriswyl, Alexandre Dumoulin ... Esther T Stoeckli
    Endoglycan fine-tunes the interaction between guidance molecules and surface receptors during axon guidance and cell migration.
    1. Cell Biology
    2. Immunology and Inflammation

    CD56 regulates human NK cell cytotoxicity through Pyk2

    Justin T Gunesch, Amera L Dixon ... Emily M Mace
    CD56/NCAM, the prototypical marker of human natural killer cells, promotes lytic function towards susceptible target cells by signaling through protein tyrosine kinase 2 (Pyk2).
    1. Neuroscience

    Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice

    Li Fan, Yichao Lu ... Qiang Wu
    A general cytoplasmic signaling mechanism for the novel functions of diverse alpha protocadherins in cortical neuron migration and actin cytoskeletal dynamics as well as dendrite morphogenesis in the brain.