A lipid mediator lysophosphatidic acid (LPA) derived from fibroblastic reticular cells regulates T-cell movement through the densely packed reticular network in lymph nodes in a manner dependent on the LPA receptor LPA2-ROCK-myosin II.
A ubiquitin E3 ligase localizes to focal adhesions at the front of migrating human cells where it regulates cytoskeletal dynamics by targeting a focal adhesion protein.
Hironobu Okuno, Francois Renault Mihara ... Hideyuki Okano
Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
Jacopo Di Russo, Jennifer L Young ... Joachim P Spatz
The use of nanopatterned hydrogels and specific integrin α5β1 peptidomimetic revealed that keratinocytes require an optimum inter-ligand spacing to best propagate intercellular forces and efficiently coordinate cell sheet migration.
CD56/NCAM, the prototypical marker of human natural killer cells, promotes lytic function towards susceptible target cells by signaling through protein tyrosine kinase 2 (Pyk2).
A general cytoplasmic signaling mechanism for the novel functions of diverse alpha protocadherins in cortical neuron migration and actin cytoskeletal dynamics as well as dendrite morphogenesis in the brain.