Profiling the adipocyte secretome reveals LRG1 as a novel adipokine that promotes insulin sensitivity and modulates inflammation triggered by release of cytochrome c from dead/dying cells, describing a new pathway at the intersection of obesity and its systemic sequelae.

Adipsin, the oldest known adipokine, has a novel role as a a regulator of bone marrow fat and, consequently, overall bone health.

Adiponectin signaling integrates metabolic state information to regulate circadian clock function in hypothalamic appetite regulating centers, food intake rhythms, and body weight.

The p.Arg707Trp mutation in Mfn2 causes adipose-specific activation of the integrated stress response, which lowers secretion of adipokines.

A novel secondary adipogenesis pathway is defined that is unique to the bone marrow and is activated with age and in states of metabolic stress.

Inhibiting triglyceride storage in adipose tissue prevents obesity and improves metabolic health.

Obese Ksr2 mutant mice have increased trabecular bone but decreased marrow adiposity and are more prone to fractures, thus providing a useful model to understand how stem cells can be manipulated to produce bone at the expense of marrow fat.

The potential metabolic mechanisms that underly the growing prevalence of long COVID are explored and potential treatments discussed.

The small macrophage-secreted protein RELMα is a sex-specific protein that protects against diet-induced obesity through regulating the macrophage–eosinophil innate immune axis in the adipose tissue.