363 results found
    1. Cell Biology

    Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

    Leilei Zhong et al.
    A newly identified adipose lineage cell population, MALP, regulates marrow vasculature and osteogenesis in bone.
    1. Cell Biology

    Limitation of adipose tissue by the number of embryonic progenitor cells

    Kristina Hedbacker et al.
    The size of subcutaneous, but not visceral, fat depots is dependent on the number of embryonic adipocyte progenitors.
    1. Physics of Living Systems
    2. Neuroscience

    Physical limits to magnetogenetics

    Markus Meister
    Recent reports on the ability of biological molecules to sense magnetic fields are found to be inconsistent with basic physical principles.
    1. Cell Biology

    Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

    Laura Le Pelletier et al.
    Aging is associated with stress-induced senescence of adipose stromal cells, leading to impaired adipogenesis, oxidative stress, mitochondrial dysfunction, and insulin resistance, all being alleviated by metformin treatment of adipose stromal cells.
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu et al.
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells

    Jiajia Xu et al.
    CD107a expression divides osteogenic from adipogenic perivascular precursor cells within human white adipose tissue.
    1. Cell Biology
    2. Medicine

    MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice

    Shilpak Bele et al.
    Class 1 histone deacetylase (HDAC) inhibitor MS-275 enhances the efficacy of glucagon-like peptide 1 receptor (GLP-1R) therapy for glycemic control and reduction of obesity.
    1. Stem Cells and Regenerative Medicine

    Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway

    Nguyen PT Huynh et al.
    Bioinformatic analysis of mesenchymal stem cell chondrogenesis identified a novel long noncoding RNA, GRASLND, which suppresses interferon signaling and enhances chondrogenesis.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Human perivascular stem cell-derived extracellular vesicles mediate bone repair

    Jiajia Xu et al.
    Perivascular extracellular vesicles induce bone repair, and do so via tetraspanin binding to recipient skeletal progenitor cells.
    1. Genetics and Genomics

    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

    Robert N Helsley et al.
    Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.

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