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Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity
Eiko Iwakoshi-Ukena et al.
Neurosecretory protein GL, a previously unknown mammalian neuropeptide, is a novel hypothalamic factor which regulates feeding behavior and peripheral lipogenesis in animals.
Computational and Systems Biology
A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice
Michael A Petr et al.
A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish
Dianne Lumaquin et al.
A novel transgenic lipid droplet reporter in transparent
zebrafish allows direct visualization of individual lipid droplets in a living animal.
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice
Chelsea Hepler et al.
Fibro-inflammatory progenitors represent a subpopulation of perivascular cells in visceral adipose tissues of mice that promote inflammation and fibrosis.
Insulin regulates POMC neuronal plasticity to control glucose metabolism
Garron T Dodd et al.
Feeding and fasting associated alterations in proopiomelanocortin neuronal responses to insulin coordinate glucose metabolism.
Increase in clinically recorded type 2 diabetes after colectomy
Anders B Jensen et al.
This nationwide register-based study of diabetes risk after colectomy suggests that the left colon contributes to maintenance of glucose homeostasis.
Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice
Yu Shi, Fanxin Long
Targeted activation of Hedgehog signalling via Gli2 facilitated the reduction of high-fat-diet-induced obesity and improvement of whole-body glucose tolerance and insulin sensitivity in adult mice.
Biochemistry and Chemical Biology
Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis
Madlen Matz-Soja et al.
The Hedgehog signalling pathway is a master regulator of lipid metabolic processes and their zonation in the adult liver of mice and humans.
Genetics and Genomics
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning
Yi Liu et al.
Systematic quantification of abdominal organ health parameters using deep learning generates new insights into the genetic architecture of cardiometabolic health traits.
Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes
Danielle Yi et al.
Dot1l and its H3K79 methyltransferase activity are required for thermogenesis, and Dot1l is recruited by Zc3h10 to its targets genes to alter chromatin accessibility to activate the thermogenic gene program.
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