The activation of beige adipocyte thermogenesis by cold temperatures and β3-adrenergic receptor agonists induce beige adipocyte formation, function and perdurance.

β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.

Selective activation of locus coeruleus noradrenergic terminals drives anxiety-like behaviors through activation of β-adrenergic receptors in the basolateral amygdala.

In mouse brain slices, native delta glutamate receptors carry ionic current and underlie the α1-adrenergic receptor-mediated depolarization of dorsal raphe neurons that drives action potential firing in vivo.

β2-adrenergic receptors control glucose metabolism by regulating cross-talk between pancreatic islet endocrine cells and vasculature during development.

Atomistic simulations reveal how lipids can allosterically modulate membrane receptors.

Hindsight/RREB-1 plays a conserved role in follicle maturation and ovulation by sequential upregulation of matrix metalloproteinase and adrenergic receptor in follicle cells.

FRET biosensor-based measurement of cAMP signaling and single-channel recording reveal that β-blockers trigger local activation of adrenergic receptors and calcium channels in primary neurons.

Differences in the kinetics of G protein activation can explain why only some receptors can activate potassium ion channels called GIRKs.

Enhanced Gq-signaling-mediated activation of forebrain excitatory neurons in postnatal life programs enhanced anxiety-, despair- and schizophrenia-like behavior, recapitulating key aspects of the behavioral consequences of early life adversity.