Transsynaptic mapping of the postsynaptic connections of mushroom body output neurons reveal both divergent and convergent projections allowing for multimodal integration prior to initiation of an output response.
Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
Stem cell migration underlies head regeneration in the cnidarian (jellies and their kin) Hydractinia, but the regeneration of other body parts is based on the gradual transformation of one tissue type into another.
LRRK2 G2019S knock-in mice are a genetically faithful model that recapitulates the slow disease progression of familial PD, with initial alterations to behaviour and neurotransmission providing early pathophysiological targets for neuroprotective interventions.
In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.