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    1. Genetics and Genomics
    2. Neuroscience

    The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

    Yifei Weng, Shiyi Zhou ... Coleen T Murphy
    Neuron-specific sequencing of aged wild-type, daf-2, and daf-16;daf-2 mutants revealed transcriptomic changes with age, and in longevity mutants, putative neuroprotective genes are upregulated, which are required for prolonged cognitive functions.
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof, Catarina Osório ... Martijn Schonewille
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
    1. Cell Biology

    Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

    Irina L Rempel, Matthew M Crane ... Liesbeth M Veenhoff
    In replicative ageing yeast cells, an age-dependent impediment in proper assembly of nuclear pore complexes is associated with altered nuclear transport.
    1. Neuroscience

    Novelty and uncertainty differentially drive exploration across development

    Kate Nussenbaum, Rebecca E Martin ... Catherine A Hartley
    From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.
    1. Neuroscience

    Functional brain alterations following mild-to-moderate sensorineural hearing loss in children

    Axelle Calcus, Outi Tuomainen ... Lorna F Halliday
    Mild-to-moderate sensorineural hearing loss causes changes in the neurophysiological functioning that emerge during adolescence, as suggested by both cross-sectional and longitudinal designs.
    1. Neuroscience

    NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning

    Felix C Widmer, Sean M O'Toole, Georg B Keller
    Prediction error responses in layer 2/3 of mouse visual cortex are shaped by experience-dependent modifications of the local cortical circuit.
    1. Chromosomes and Gene Expression

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch, Mariona Font-Llitjós ... Virginia Nunes
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Neuroscience

    Freezing suppression by oxytocin in central amygdala allows alternate defensive behaviours and mother-pup interactions

    Elizabeth Rickenbacher, Rosemarie E Perry ... Marta A Moita
    Oxytocin in the amygdala suppresses freezing of mothers when exposed to a threat in the presence of their offspring, allowing for pup protection and transmission of information about danger from mothers to pups.
    1. Neuroscience

    Songbirds can learn flexible contextual control over syllable sequencing

    Lena Veit, Lucas Y Tian ... Michael S Brainard
    Songbirds can use arbitrary visual cues to immediately, flexibly and adaptively control syntax of learned song vocalizations in a manner that parallels human cognitive control over syllable sequencing in speech.
    1. Neuroscience

    A neural circuit mechanism for regulating vocal variability during song learning in zebra finches

    Jonathan Garst-Orozco, Baktash Babadi, Bence P Ölveczky
    By demonstrating song learning-related synaptic strengthening and pruning in the vocal control circuits of songbirds, and showing how such changes can reduce the sensitivity of the circuit to ‘noisy’ inputs, a simple neural circuit mechanism for regulating motor variability during motor skill learning is identified.